Abstract
Dihydroquinolines have been synthesized and have been shown to be potent n-NOS inhibitors. Selectivity versus e-NOS was increased to approximately 100-fold through appropriate substitution at the benzene ring.
MeSH terms
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Nitric Oxide Synthase / antagonists & inhibitors*
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Nitric Oxide Synthase Type I
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Quinolines / chemistry
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Quinolines / pharmacology*
Substances
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Enzyme Inhibitors
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Quinolines
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type I